Magic Angle Spinning (MAS) Probes
The NMR Instituut, led by Prof. Ago Samoson, has been a chief innovator of MAS NMR probes for many years. Prof. Samoson has numerous publications and patents, which are reflected in the innovation of these leading edge probes.
NMRi offers the highest speed and sensitivity, particularly important for the rapidly expanding field of bio-solids. NMRi offers a range of sample sizes which dictate the maximum spinning speed.
NMRi probes share many convenient features allowing even novice users to obtain excellent results
• CNH, XH and other tuning options cross coil (low heating) optimized for 13C
• low power decoupling
• >100 kHz optimized for 1H sensitivity
• largest sample volume for each speed
• -160° .. +400°C
• temperature “shimming”
• universal MAS controller and logger
• in situ flow, fast temperature change
• sensor assisted rotor service toolkit
• any liquids/solids console compatibility
• NB/WB magnet
• probe lift
• remote angle control
• C, H pulse < 3 us
• N pulse < 5 us
• 45 kHz- low power decoupling, biological 13C work
• 25 kHz- standard probe for hi-res consoles
• 15 kHz- max S/N (requires high power amplifiers)
• VT -160 ..+150 C
Wickramasinghe, N.P.; Parthasarathy, S.; Jones, C.R.; Bhardwaj, C.;
Long, F.; Kotecha, M.; Mehboob, S.; Fung, L.W-M.; Past, J.; Samoson, A.; Ishii, Y. (2009).
Nanomole-scale protein solid-state NMR by breaking intrinsic 1H T1 boundaries. NATURE METHODS, 6 (3), 215−218
Ernst, M.; Samoson, A.; Meier, BH. (2003). Low-power XiX decoupling in MAS NMR experiments.
Journal of Magne^c Resonance, 163 (2), 332−339.
400 MHz 3mm rotor
600 MHz 4mm rotor
- H optimized rf (HXN)
- volume optimized rotors for 100 (0.81mm) and 150 (0.51mm) kHz
- top speed 170 kHz
- VT-170… +150C
- 1H: <10W @ 172 kHz (1.45 us)
- 15N: <30W @ 62.5 kHz (4us)
- 13C: <25W @ 83.3 kHz (3us)
600 1H/13C/15N, 50 is a three radio frequency channel probe, optimized for 1H detection. The second and thrid probe channel is tuned either to 13C or 15N, respectively and can be used for simultaneous decoupling. The probe is equipped with actively shielded single-axis gradient. All channels including lock can be tuned and matched without removing the probe. The probe can be operated at temperatures between -50ºC and +100 ºC using the appropriate accessories (not included).
- All channels tune-and match-able, lock included
- Actively shielded Z-gradient and 2H lock
- Superior water suppression
Rotor Service Instrumentation
• spinning quality
• rotor longevity
160 kHz MAS
1H detected CC and CN @150 kHz MAS
HN @150 kHz MAS
Agarwal V et al (2014) De novo 3D structure determination from sub- milligram protein samples by solid-state 100 kHz MAS NMR spectroscopy. Angew Chem Int Ed 53:12253–12256
Sternberg U et al (2018) 1H line width dependence on MAS speed in solid state NMR—comparison of experiment and simulation. J Magn Reson 291:32–39
Lin Y-L et al (2018) Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles. Chem Commun 54:10459–10462
Susanne Penzel, Andres Oss, Mai-Liis Org, Ago Samoson, Anja Böckmann, Matthias Ernst, Beat H. Meier, Spinning faster: protein NMR at MAS frequencies up to 126 kHz, Journal of Biomolecular NMR 73:19-29,2019
A. Samoson, H-MAS, J Magn Reson, 2019, 306, 167-172.
Alexander A. Malär, Susanne Smith-Penzel, Gian-Marco Camenisch, Thomas Wiegand, Ago Samoson, Anja Böckmann, Matthias Ernst and Beat H. Meier, Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach, DOI: 10.1039/c9cp03414e, PCCP 2019
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