Q One Platform

400/500/600 MHz

Full Automation

Our goal: New, innovative products for applications across the field of NMR

400 MHz Sample Data

Results Library

Cyclosporine
Cholesterol
Strychnine
HOPS Extract
Menthol

25 mg cyclosporine in 0.6 mL C₆D₆

¹H-¹H COSY spectrum of 25 mg cyclosporine in 0.6 mL C₆D₆

HSQC Spectrum of 25 mg cyclosporine in 0.6 mL C₆D_{61H-¹⁵N HSQC Spectrum of 25 mg cyclosporine in 0.6 mL C₆D₆}

100 mg cholesterol in 0.6 mL CDCl₃

100 mg cholesterol in 0.6 mL C₆D₆

¹H NMR Spectrum of Strychnine

¹H-¹H COSY NMR Spectrum of Strychnine

50 mg of hops extract from melloeX liquid CO₂ extraction of Warrior hops.

¹³C spectrum of 50 mg of Warrior Hops extract using the melloeX liquid CO₂ extractor

¹ H
¹³C
¹H-{¹H} COSY
¹H-{¹³C} HSQC

5% Menthol in CDCl₃

5% Menthol in CDCl<sub>3</sub>

5% Menthol in CDCl₃

Applications

Chemistry Education

Industry

Research

Pharma

Specifications

Pulse Sequence Control System Distributed pulse sequence control system with ethernet based digital transmitter and receiver system integrated by high reliability CAN controller network featuring:

High speed Gigabit network connection
Transmitter and receive channels can be extended to 3 channels
CAN controller nodes can be expanded to more than 110 to accommodate multiple transmit/receive channels and gradient controllers with simple cables connections
Modular design — convenient for maintenance and repair

Transmitter Specifications:

Intermediate Frequency 922.5 MHz
Event minimum and resolution 25 nsec
Resolution 0.01 Hz
Phase Resolution 0.02°
Minimum Pulse Width 100 nsec
Console pulse power 0 dBm
Power resolution 0.01 dB
Attenuation Range -40 to +63 dB
Power Linearity 99.9 %
Power Stability 0.3 dBc
Transmit harmonic suppression > 50 dBc

Receiver Specifications:

Dynamic Range ≥80 dB
Sampling Rate 60 mega samples per second
Programmable bandwidth 120 Hz to 2.5 MHz
Digital Resolution 14 bit
Gain Range -30 to 40dB
Gain Resolution 1 dB

Three Channel RF Power Amplifier

Maximum Duty Cycle 10 %
Maximum Pulse Width 250 msec
Deuterium Channel 30 to 120 MHz pulse power > 15 watts
High Frequency Channel 180 to 600 MHz
Maximum linear pulse power > 140 watts
Maximum CW power 35 watts
Maximum duty cycle 10%
Maximum pulse width 200 msec
Rise and fall times < 100 nsec and < 50 nsec, resp.
Blanking time < 2µsec
Broad Band Power Amplifier 10 MHz to 410 MHz
Maximum linear peak pulse power
10-100 MHz 200 watts
100-200 MHz 330 watts
280-410 MHz 100 watts
Maximum CW power 30 watts
Pulse rise and fall time 100 nsec and 50 nsec, resp.
Blanking Time < 2µsec

Gradient Controller 3 channel integrated with pulse programmer with digital pre-emphasis.

Peak Output Current ± 10 Amps
Maximum duty cycle 10 %
Max Pulse Width 150 msec
Digital Resolution 16bit
Load Capacity < 1.2 ohms < 15 µH
Rise Times
< 20 µsec 10 % to 90 %
< 30 µsec 10 Amps
Output linearity 99.9 %
Frequency range < 20 kHz

Preamplifier True broadband transmit/receive switch technology w/additional receive modules; 7” color OLED monitor displays status and probe tuning curves and supports Smart Tuning and Matching (STM) probes.

Insertion Loss < 1 dB
Peak pulse power > 500 Watts
Transmit/Receive Switching Time < 2 µsec; Isolation ≥ 40 dB
Noise figure < 1.5 dB; gain > 32-45 dB; flatness < 1 dB

Room Temperature Shim System

40 channels; 1 Amp max current
Temperature drift < 10 ppm per °C
Digital resolution 16 bits

Temperature and Pneumatic Control

Spinning Speed Range 10 to 40 Hz
Rotational Stability ± 1 Hz
Temperature Control Range -40 °C to +150 °C
Temperature Stability ± 0.1 °C

Installation Guide

Quantum-I-Plus 400 Installation Guide

Introduction
Safety
User Representative
Quantum-I-Plus Automation
Installation Process Overview
Installation Site Requirements
General Site Considerations
Laboratory Entrance Clearance
Laboratory Space and Load Requirements
Ventilation
Vibration, Humidity, Temperature
Particulate Matter
Compressed Air
Electrical Power
Installation Requirements
Cryogens for Magnet Installation
Magnet & Autosampler Support Requirement
Instrument Arrival
Inspection
Unpacking and Installing
Cryogenic Equipment Rack
Preventive Maintenance

Introduction

The Pre-installation Instructions guide you through each requirement on the checklist. Have the completed checklist available when you call to schedule the installation. If you have any questions about the requirements listed in this document, contact Q.One Customer Service.

The Quantum I-Plus 400 operates under the environmental conditions specified in this document. The Warranty and Service contract specifically excludes the repair of failures caused by nonconforming environmental conditions.

CAUTION

All phases of the installation site preparation must conform to local safety, electrical, and building codes. These codes take precedence over any recommendations in these instructions, and the customer is responsible for compliance.

Safety

Requirement: The installation site is in compliance with all relevant safety regulations.

Safety is the most important consideration for instrument installation and use. Determine if the installation site complies with all relevant local safety regulations and codes.

User Representative

Schedule the installation when the User Representative is available, because one of the important duties of the Q.One Representative is to familiarize the User Representative with the basic functions of the Quantum I-Plus 400.

Requirement: User representative must be available during installation, calibration and acceptance.

Quantum-I-Plus Automation

The Quantum-I-Plus 400 automation suite is a collection of accessories that enhance flexibility, ease-of-use, and sample throughput.

STM Probe with auto-tuning
Autosampler for running queued samples

Site preparation requirements for these accessories are provided in this document. The STM probe and autosampler have no requirements that are not covered by the Quantum-I-Plus 400.

Installation Process Overview

The duration of the complete Quantum-I-Plus 400 system installation, including the automation accessory is 12 days. The daily milestones are show below.

Day 1: Unpack, inventory, assemble magnet & under vacuum; being assembling components.
Day 3: Pre-cool magnet and install software on workstation
Day 4: Cool magnet and test console functionality; perform rf calibration
Day 5: Energize magnet.
Day 8: Complete SC shimming; Start Gradient shimming
Day 9: Complete autosampler installation and gradient shimming
Day 10: Complete 3D shimming, run probe calibrations and tests
Day 11: Complete automation set-up and testing
Day 12: Begin User training and familiarize user with basic operations

Installation Site Requirements

This section describes requirements for the system installation site. Each requirement must be met before an installation can be scheduled. Contact your installation coordinator if you have any questions about the requirements.

General Site Considerations

Requirement: Instrument will be far enough away from external sources of vibrations and magnetic fields.

When choosing an installation site for the system, consider how the external environment, particularly external sources of vibrations and electromagnetic fields, might affect the system.

External Environmental Considerations

Consideration	Min. Distance from System (ft)	Min. Distance from System (m)	Possible Effect on System
Elevators	25	7.6	Vibrations, magnetic field
Stairwell, loading dock, compressor, heavy equipment/machinery	25	7.6	Vibrations
Electric trains/trams	1640	500	Magnetic field
High voltage lines & transformers	164	50	Magnetic field
High-field electromagnets, forklift trucks	15	4.6	Magnetic field

Laboratory Entrance Clearance

Verify that there is sufficient entrance clearance to move the shipping containers to the installation location before arranging delivery.

Shipping Container	Height (in/cm)	Width (in/cm)	Depth in/cm	Weight lb/kg
Magnet	68/171	44/110	49/124	1353/615
AV legs	22/55	47/129	41/105	344/156
Console	46/117	27.5/70	40/102	390/177
Accessories	42/107	51/120	41/105	230/105

Requirement: Entrance and access to the installation location is adequate for system crates and pallet jacks.

Laboratory Space and Load Requirements

The following information is provided to help you plan the layout of your system. The Q.One Representative will unpack the boxes and place the modules in the final location. The console may also be placed to the left of the magnet. Sufficient space must be maintained around the system for air circulation and service access.

Requirement: Sufficient laboratory space including service access
Requirement: Floor can support system weight

Ventilation

In the unlikely event of a magnet failure, or quench, the evaporated helium is rapidly exhausted from the manifold by the pressure relief valves. The exhausted gas will displace oxygen and cause asphyxiation if the room is not properly ventilated. Review the following considerations with a safety engineer:

The magnet holds about 64 L of liquid helium. A magnet quench will not typically boil off the entire 64 L.
During a quench, helium gas fills the room from the ceiling down, so set up fans accordingly.
The expansion ratio of liquid helium at room temperature is about 740:1, which means that one liter of liquid helium expands to about 740 liters of helium gas. To calculate CFM, use 26.13, which includes the expansion ratio.

Vibration

Requirement: Floor vibrations are within the specified limits

High levels of vibration can have an adverse affect on the quality of NMR data. The Quantum-I-Plus 400 is equipped with state-of-the-art vibration isolation equipment. Ground floor or basement sites are generally preferred for systems because the natural resonant frequencies of most building structures are typically at low frequencies and horizontal in direction. Also, cement slabs on grade are generally stiffer with less low-frequency vibrations and preferred to suspended floors.

Frequency of Vibration	Restriction
Greater than 15 Hz	no single peak greater than 400 µg
10 to 15 Hz	no single peak greater than 200 µg
5 to 10 Hz	no single peak greater than 75 µg
Less than 5 Hz	no single peak greater than 10 µg

You can order a site inspection before the installation if there are any concerns relating to possible vibrations (especially older construction buildings and/ or laboratories sited on third floors or higher). Contact Customer Service for more details.

Humidity

Requirement: Relative humidity can be maintained within the specified range.

Operating the system at a very low humidity may result in the accumulation and discharge of static electricity, shortening the life of electronic components. Operating the system at high humidity may produce condensation and result in short circuits. Suggested humidity range is 20% to 80% non-condensing.

Temperature

Requirement: Lab temperature can be maintained within the specified range.

The average steady-state heat load of the console is 500 watts. The host workstation heat load is approximately 400 watts.

The airflow around the system must be adequate. The air conditioning system must be capable of maintaining a constant temperature in the immediate vicinity of the system. The temperature around the magnet must be maintained within ±1.0 °C (±1.8 °F) during an experiment and during shimming. Do not place the system near air ducts, windows, or heating and cooling systems. Optimal operating temperature is 60-75 °F or 17-24 °C.

NOTE: As laboratory temperature increases, system reliability decreases due to heat generated by electronic components. This heat must dissipate to the surrounding air for reliable operation.

Particulate Matter

Requirement: Lab is free from excessive particulate matter.

The laboratory must not have excessive dust, smoke, or other particulate matter. Particulate matter can block airflow vents causing the electronics to overheat.

Compressed Air Requierments

Requirement: Compressed air or nitrogen is clean and dry, and the appropriate regulator and gas lines are installed.

Quantum-I-Plus 400 system operation requires a constant flow rate of air or nitrogen. Install the air supply with 1⁄4 in. (0.635 cm) connectors.

If compressed air will be used, it must be clean, dry, and oil-free, with less than 0.1 ppm total hydrocarbons, including methane, and a −40 °C dew point.
If compressed nitrogen will be used for the system supply, the gas must be dry, oil-free, and magnetically clean (for example, free of rust), with a dew point of –193 °C (80 K).

Specification	Condition	Flow Rate	Pressure
Quantum-I-Plus	Sample Insert	45 lpm (95 SCFH)	80 psig (585 kPa)
Quantum-I-Plus	Normal operation	27 lpm (57 SCFH)	80 psig (585 kPa)

Compressor		100 lpm (127 SCFH)	100 psig (585 kPa)

You are responsible for conforming to all regulations regarding the installation and operation of the compressed air system.

Electrical Power

Requirement: Specified electrical supply and power outlets are installed.

The Quantum-I-Plus 400 system requires a single-phase power source with earth grounds hard-wired to the main power panel ground.

Component	Max. Current Demand 180-246 VAC	Number of Outlets
Console	5	1
Computer	3	1
Monitor	1	1
Printer	3	1

Installation Requirements

Requirement: The necessary supplies and equipment will be available for the system installation.

This section describes the requirements to ensure a successful installation. The lab should have adequate helium and nitrogen gas for magnet installation.


Helium	2 cylinders about 80,000 liters or 285 cu. ft. Low pressure regulator less than 30 psi He gas flow regulator and flow meter 0-40 lpm (0-80 CFH) Purity ≥ 99.995% or US Bureau of Mines Grade A.
Nitrogen	1 cylinder or a fixed source Dry, oil free and magnetically clean with a dew point of -193 °C

Cryogens for Magnet Installation

Liquid helium and liquid nitrogen are required for the magnet installation. You should request delivery of the cryogens on the morning of, or on the day before the start of the installation to minimize loss due to boil off.


Helium	400 liters 200 liters at short notice delivery within 48 hours. Dewar should be compatible with a siphon diameter of 0.5 in (12.7 mm)
Nitrogen	700 liters Adapter for connecting 9 mm (3/8 in) ID rubber tubing to the LN2 container.

Magnet Support Requirements

Requirement: The appropriate facilities engineer and tools will be available to assist the field service engineer during magnet installation.

Facilities personnel must be available during the magnet installation to assist with drilling holes for anchor bolts.

The magnet anti-vibration legs must be fastened to the floor. Q.One supplies four 1⁄2-inch diameter anchor bolts for each leg. A minimum depth of 2.5 in is required for each bolt. A drawing shows the bolt hole pattern.

The magnet can also be supported by ropes attached to the ceiling. If overhead ropes are used, the ceiling of the building should be evaluated for structural strength. The ropes should have a small amount of slack so that building vibrations are not transmitted to the magnet. These vibrations can cause artifacts to appear in the NMR spectra.

Instrument Arrival

Requirement: The shipping cartons were examined for damage, and if damaged, the conditions were reported and noted on the freight weigh bill.

Inspection

When the Quantum-I-Plus 400 arrives, carefully inspect the exterior of the shipping cartons for evidence of any damage that might have occurred during shipment. Inspect the cartons for the following:

Water stains
Cuts, punctures, or deep indentations
Crushed corners or excessively abraded edges
Blue beads in the Tip (N) Tell arrow point
Two Tip (N) Tell indicators and labels are on the exterior of the shipping boxes. Read and follow the instructions on the label. If the Tip (N) Tell arrow point is blue, the box was on its side or tipped in transit and instrument damage may have occurred.
If you see one or more of these conditions on any shipping carton:
- Report the conditions to the carrier when you receive the shipment
- Note the damage on all copies of the shipping documents
- Write a brief description of the damage
- Tell the driver to sign next to your comments to signify agreement with the observations
- Contact local Customer Service to report the damage
- If no external damage is apparent, sign the receiving documents “Received but not inspected” to indicate that the boxes have not been opened.
- Systems are shipped either FOB Shipping Point or FOB Destination. The manner of shipment determines who is responsible for filing a claim against the carrier if the system was damaged in transit. Most systems are shipped FOB Shipping Point, so any damages incurred in shipment are the responsibility of the purchaser and the carrier. Contact local Customer Service for assistance with filing claims and billing repairs. If the system is shipped FOB Destination, contact local Customer Service, which will file a claim against the carrier.
- Q.One will not accept liability for damage if obviously received damaged materials were received without noting the damage on the receiving documents.
- Move the shipping containers to a warm, dry, secure area near the place of installation.
- Do not open any boxes until the Q.One Representative arrives to do the installation.

Unpacking and Installing

The Installation Coordinator will review the pre-installation checklist with you to ensure that you have satisfied all of the site requirements. The installation engineer will unpack and install the instrument and demonstrate the fundamental operation and maintenance procedures. The principal operator must be available during the installation. The installation engineer will follow an installation process that leaves the system calibrated and optimized for standard NMR experiments. The Installation Engineer will then demonstrate magnet safety and maintenance and basic NMR operation.

Plan to analyze your samples only after the installation is completed and you have accepted the system.

Cryogenic Equipment Rack

Various items are used around the magnet for routine maintenance and cryogen handling, including a helium transfer tube, Tygon® tubing, and insertion tubes. Protect the cryogenic equipment from damage and keep it conveniently available. Provide a rack to hold the items. A 1.2 m x 2.4 m (4 ft x 8 ft) pegboard hung on a wall, with wood/plastic pegs, works very well.

Preventative Maintenance

Routine and preventive maintenance is the customer’s responsibility. Any instrument problems resulting from, for example, contaminated gas or cryogen supplies, poorly controlled line voltage, and so on, are billable and not included in the warranty.

Perform regular preventive maintenance to increase the life of the system, maximize system uptime, and maintain system performance. Your Q.One Americas Representative will describe and demonstrate these procedures during the installation.

Q.One Americas offers a wide variety of service and maintenance plans that will ensure system operation. Contact your local Q.One Americas Representative for details.